MDD	Major depressive disorder
SSRIs	Selective serotonin reuptake inhibitors
STAR*D	Sequenced Treatment Alternative to Relieve Depression
LC-MS/MS	Liquid chromatography tandem mass spectrometry
MEM	mixed-effect model
GEE	generalized estimating equation
LMM	Linear mixed model
LC-MRM/MS	Liquid chromatography-multiple reaction monitoring/mass spectrometry
LFQ	Label-free quantification
SD	Standard deviation
MADRS	Montgomery and Asberg Depression Rating Scale
CGI-S	Clinical Global Impression-Severity
BDI	Beck’s Depression Inventory
HAM-D	Hamilton Rating Scale for Depression
CUDOS	Clinically Useful Depression Outcome Scale
GO	Gene ontology
SGoF	Sequential goodness of fit metatest
t-SNE	t-stochastic neighbor embedding
PsyGeNet	Psychiatric disorders gene association network
PsychoQOL	Psychological quality of life
DBH	Dopamine beta-hydroxylase
NSF	Normalization scaling factor