Table 2.
37 differentially abundant proteins corresponding to response/time interaction.
| UNIPROT Accession | Adjusted p-Value | Gene Name | Protein Name | Cluster No. | COR a |
|---|---|---|---|---|---|
| P04278 | 2.70 × 10-3 | SHBG | Sex hormone-binding globulin | 5 | 0.12 |
| P05090 | 2.95 × 10-3 | APOD | Apolipoprotein D | 6 | −0.34 b |
| Q06033 | 4.01 × 10-3 | ITIH3 | Inter-alpha-trypsin inhibitor heavy chain H3 | 5 | −0.21 |
| P08567 | 4.36 × 10-3 | PLEK | Pleckstrin | 4 | 0.04 |
| P04275 | 4.69 × 10-3 | VWF | von Willebrand factor | 6 | −0.19 |
| P52566 | 5.11 × 10-3 | ARHGDIB | Rho GDP-dissociation inhibitor 2 | 1 | −0.15 |
| P02656 | 6.89 × 10-3 | APOC3 | Apolipoprotein C-III | 6 | −0.06 |
| P06276 | 7.13 × 10-3 | BCHE | Cholinesterase | 6 | −0.11 |
| P27169 | 8.89 × 10-3 | PON1 | Serum paraoxonase/arylesterase 1 | 5 | −0.08 |
| P22105-4 | 9.85 × 10-3 | TNXB | Tenascin-X | 6 | −0.25 |
| P02774-3 | 1.09 × 10-2 | GC | Vitamin D-binding protein | 5 | 0.04 |
| P0C0L5 | 1.10 × 10-2 | C4B | Complement C4-B | 5 | −0.21 |
| P02649 | 1.15 × 10-2 | APOE | Apolipoprotein E | 6 | −0.04 |
| P07339 | 1.45 × 10-2 | CTSD | Cathepsin D | 4 | 0.02 |
| Q92820 | 1.50 × 10-2 | GGH | Gamma-glutamyl hydrolase | 5 | −0.01 |
| P09172 | 1.69 × 10-2 | DBH | Dopamine beta-hydroxylase | 2 | 0.03 |
| P40189 | 1.75 × 10-2 | IL6ST | Interleukin-6 receptor subunit beta | 4 | 0.15 |
| Q8NBP7 | 1.81 × 10-2 | PCSK9 | Proprotein convertase subtilisin/kexin type 9 | 3 | −0.14 |
| Q16610 | 1.83 × 10-2 | ECM1 | Extracellular matrix protein 1 | 2 | 0.02 |
| P62258 | 1.83 × 10-2 | YWHAE | 14-3-3 protein epsilon | 6 | 0.18 |
| P80188 | 1.83 × 10-2 | LCN2 | Neutrophil gelatinase-associated lipocalin | 6 | −0.11 |
| Q9H299 | 1.99 × 10-2 | SH3BGRL3 | SH3 domain-binding glutamic acid-rich-like protein 3 | 1 | 0.13 |
| P27918 | 2.05 × 10-2 | CFP | Properdin | 6 | 0.08 |
| P08571 | 2.12 × 10-2 | CD14 | Monocyte differentiation antigen CD14 | 2 | 0.24 |
| P08697 | 2.33 × 10-2 | SERPINF2 | Alpha-2-antiplasmin | 5 | 0.22 |
| P36980 | 2.34 × 10-2 | CFHR2 | Complement factor H-related protein 2 | 4 | 0.16 |
| P08253 | 2.57 × 10-2 | MMP2 | 72 kDa type IV collagenase | 6 | 0.13 |
| P13671 | 2.65 × 10-2 | C6 | Complement component C6 | 5 | 0.13 |
| O43852-3 | 2.80 × 10-2 | CALU | Calumenin | 3 | 0.10 |
| P14543 | 2.93 × 10-2 | NID1 | Nidogen-1 | 4 | −0.05 |
| P35579 | 2.95 × 10-2 | MYH9 | Myosin-9 | 1 | 0.05 |
| P05160 | 3.70 × 10-2 | F13B | Coagulation factor XIII B chain | 6 | −0.17 |
| P02765 | 3.75 × 10-2 | AHSG | Alpha-2-HS-glycoprotein | 2 | 0.20 |
| Q99453 | 3.85 × 10-2 | PHOX2B | Paired mesoderm homeobox protein 2B | 2 | −0.12 |
| O43157 | 4.01 × 10-2 | PLXNB1 | Plexin-B1 | 5 | −0.01 |
| P06396 | 4.26 × 10-2 | GSN | Gelsolin | 6 | 0.04 |
| O43866 | 4.41 × 10-2 | CD5L | CD5 antigen-like | 3 | −0.27 |
a Spearman’s correlation coefficient of protein abundance and Montgomery and Asberg Depression Rating Scale (MADRS) for each protein. b Adjusted p-values < 0.05 on a permutated correlation test based on Spearman’s coefficient analysis.