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. 2020 Nov 3;8(11):471. doi: 10.3390/biomedicines8110471

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Gene interaction analyses. (A) The panel shows the MCM2 direct interactors identified by the EGAN software using KEGG, NCI-Nature Pathway Interaction Database, Panther, and Reactome as connections sources; the most relevant enriched pathways are also shown. Most of the interactors are listed in the Transcriptional Instability (TIN)-signature genes. (B) Pathway Commons gene interactions ‘core’ derived from the genes shortlisted in panel A. The more interconnected genes are shown revealing, besides (rule sets) and TIN-signature genes, other interactors including RPA1 and RPA2.