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The structure of VCAM-1 and its α4β1 integrin binding regions. Human VCAM-1 has two splice variants with seven or six domains. Murine VCAM-1 has also two splice variants with seven or three domains. The α4β1 integrin binds to D1 of all the splice variants, but it binds to D4 if this domain is present and depending on the activation state of the α4β1 integrin.
