Figure 4.

Images from the study of Chan et al. [87]. Detection of vulnerable inflamed plaques in mouse carotid arteries by in vivo MRI after administration of dual-MPIO (on the left) or control IgG-MPIO (on the right). In post-injection imaging after 2 h, the hypointensity signal in the aortic root was detected for dual-MPIO, but no change was observed for the control MPIO. Field of view: 25.6 mm × 25.6 mm. Acquisition matrix: 256 × 256. Reproduced with permission from Chan et al., Imaging Vulnerable Plaques by Targeting Inflammation in Atherosclerosis Using Fluorescent-Labeled Dual-Ligand Microparticles of Iron Oxide and Magnetic Resonance Imaging; published by J. Vasc. Surg., 2018.