Table 2.
Patient characteristics.
| Characteristics | Group | n (%) |
|---|---|---|
| No. of patients | 82 | |
| Gender | Female | 26 (31.7) |
| Male | 56 (68.3) | |
| Age: Median (range), y | 66.5 [33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87] | |
| ≤55 | 11 (13.4) | |
| >55 | 71 (86.6) | |
| Smoking history | Never | 31 (37.8) |
| Former/current | 51 (62.2) | |
| Stage | I | 50 (61.0) |
| II | 18 (22.0) | |
| III | 11 (13.4) | |
| IV | 3 (3.7) | |
| Nodal and/or distant metastasis | Present | 19 (23.2) |
| Absent | 63 (76.8) | |
| EGFR mutation | Present | 25 (30.5) |
| Exon 19 deletion | 14 (17.1) | |
| Exon 21 L858R | 11 (13.4) | |
| Exon 20 insertion | 0 (0) | |
| Exon 18 G719S | 0 (0) | |
| Absent | 49 (59.8) | |
| NA | 8 (9.8) | |
| Histology | MIA | 8 (9.8) |
| Lepidic | 3 (3.7) | |
| Acinar | 8 (9.8) | |
| Papillary | 34 (41.5) | |
| Micropapillary | 2 (2.4) | |
| Solid | 15 (18.3) | |
| IMA | 8 (9.8) | |
| Fetal | 2 (2.4) | |
| Pleomorphic | 2 (2.4) | |
| SNV in the rDNA promoter region | Germline | 29 (35.4) |
| Somatic | 8 (9.8) | |
| Germline and somatic (at different locus) | 2 (2.4) | |
| Total (Germline and/or somatic) | 35 (42.7) | |
| No SNV | 47 (57.3) |
NA, not assessed; MIA, minimally invasive adenocarcinoma; IMA, invasive mucinous adenocarcinoma; SNV, single-nucleotide variant; rDNA, ribosomal RNA gene, ribosomal DNA; n, number of patients.