Table 2.

Multivariable logistic regression analysis of TRG probability in rectal cancer patients pre and post-CRT.

Variable Pre-CRT	Genotype	OR TRG 1-2 vs TRG 3-5 (95% CI)	p-Value
Age at diagnosis (years)	cont.	1.03 (1.0─1.07)	0.052
rs2735940	AA		ns
	AG
	GG
rs2736098	TT		ns
	TC
	CC
rs2736108	TT	Ref
	TC	3.4 (0.8─14.4)	0.102
	CC	4.6 (1.1─19.1)	0.034
rs2853690	GG	2.7 (1.2-6.3)	0.017
	AG	Ref
	AA	9.7 (1.6─57.0)	0.012
	AA/GG	3.0 (1.3─6.9)	0.008
Variable Post-CRT	Genotype/Characteristics	OR TRG 1-2 vs TRG 3-5 (95% CI)	p-Value
Age at diagnosis (years)	cont.		ns
rs2735940	AA		ns
	AG
	GG
rs2736098	TT		ns
	TC
	CC
rs2736108	TT		ns
	TC
	CC
rs2853690	GG		ns
	AG
	AA
TERT (T2)	≤median (45)	5.8 (1.9─17.8)	0.002
	>median	Ref
ΔTERT (T2-T0)	≤0 (stable/decrease)	5.3 (1.4─19.4)	0.012
	˃0 (increase)	Ref

TRG = tumor regression grade; OR = odds ratio; CI = confidence interval; cont. = continuous variable.