Table 3.
Selected GI50 values (µM) for the antiproliferative activity of organochalcogen derivatives.
| Compound | A549 (Lung) | HBL-100 (Breast) | HeLa (Cervix) | T-47D (Breast) | WiDr (Colon) | BJ-hTert (Fibroblasts) | S.I. |
|---|---|---|---|---|---|---|---|
| 15 | 5.4 ± 1.1 | 29 ± 6 | 3.6 ± 1.1 | 39 ± 5 | 31 ± 7 | ---1 | --- |
| 16 | 3.7 ± 0.6 | 2.4 ± 0.6 | 2.3 ± 0.4 | 5.8 ± 0.9 | 3.9 ± 0.6 | 3.5 ± 0.6 | 0.6‒1.5 |
| 18 | 33 ± 5 | 34 ± 1 | 23 ± 1 | 71 ± 5 | 85 ± 21 | --- | --- |
| 20 | 28 ± 8 | 37 ± 2 | 19 ± 8 | 35 ± 1 | 41 ± 10 | --- | --- |
| 35 | 3.1 ± 0.7 | 3.5 ± 1.4 | 3.5 ± 0.8 | 3.4 ± 0.2 | 2.0 ± 0.1 | 8.7 ± 3.2 | 2.5‒4.4 |
| 36 | 1.8 ± 0.7 | 2.1 ± 0.2 | 1.2 ± 0.2 | 1.1 ± 0.3 | 1.3 ± 0.6 | 14 ± 2 | 6.7‒13 |
| 37 | Not soluble | ||||||
| 38 | 19 ± 2 | 14 ± 3 | 5.2 ± 1.0 | 4.7 ± 1.2 | 14 ± 2 | --- | --- |
| 39 | 1.2 ± 0.3 | 2.9 ± 0.6 | 2.4 ± 1.4 | 2.9 ± 0.4 | 1.6 ± 0.3 | 3.9 ± 1.0 | 1.3‒3.3 |
| 40 | 1.6 ± 0.5 | 2.0 ± 0.9 | 0.95 ± 0.07 | 0.88 ± 0.17 | 1.2 ± 0.1 | 28 ± 5 | 14‒32 |
| 41 | 32 ± 8 | 93 ± 10 | 31 ± 8 | 29 ± 5 | 29 ± 8 | --- | |
| 45 | 0.41 ± 0.03 | 1.6 ± 0.3 | 0.36 ± 0.09 | 0.40 ± 0.04 | 0.41 ± 0.03 | 1.8 ± 0.7 | 1.1‒5.0 |
| 46 | 0.27 ± 0.02 | 0.25 ± 0.02 | 0.12 ± 0.01 | 0.19 ± 0.04 | 0.25 ± 0.06 | 1.0 ± 0.1 | 3.7‒8.3 |
| Ebselen | 25 ± 9 | 13 ± 3 | 26 ± 8 | 90 ± 14 | >100 | --- | --- |
| CDDP | 4.9 ± 0.2 | 1.9 ± 0.2 | 2.0 ± 0.3 | 15 ± 2 | 26 ± 6 | 14 ± 2 | 0.5‒7.4 |
1 Not tested.