Table 1.

Some of the most important AFP models proposed in the past years.

Name	Reference	Input Data	Method
GOLabeler	[3]	Amino acid sequence, GO term frequencies	Learning to rank
FunFams	[4]	Amino acid sequence	Hidden Markov Model
INGA	[5]	Amino acid sequence	Homology search, enrichment analysis
PFP	[6]	Amino acid sequence	Phylogenetics
COFACTOR	[7]	Amino acid sequence, protein structure, protein interactions	Homology search, structural similarity
NetGO	[8]	Amino acid sequence, GO term frequencies, protein interactions	Learning to rank
DeepGOPlus	[9]	Amino acid sequence	Convolutional neural network, homology search

AFP: Automatic Function Prediction. GO: Gene Ontology.