Table 4.
Metabolic pathways corresponding to metabolites identified in AH samples.
| Pathway | No. of Metabolites in the Pathway | No. of Metabolites Detected in AH | p-Value | Pathway Impact |
|---|---|---|---|---|
| Arginine biosynthesis | 14 | 4 | 0.000028 | 0.30 |
| Alanine, aspartate and glutamate metabolism | 28 | 2 | 0.058 | 0.21 |
| Glyoxylate and dicarboxylate metabolism | 32 | 2 | 0.074 | 0.024 |
| D-Glutamine and D-glutamate metabolism | 6 | 1 | 0.082 | 0.0 |
| Nitrogen metabolism | 6 | 1 | 0.082 | 0.0 |
| Pyrimidine metabolism | 39 | 2 | 0.10 | 0.06 |
| Aminoacyl-tRNA biosynthesis | 48 | 2 | 0.15 | 0.0 |
| Pantothenate and CoA biosynthesis | 19 | 1 | 0.24 | 0.0071 |
| Citrate cycle (TCA cycle) | 20 | 1 | 0.25 | 0.12 |
| Sphingolipid metabolism | 21 | 1 | 0.26 | 0.15 |
| Pentose phosphate pathway | 22 | 1 | 0.27 | 0.0 |
| Pyruvate metabolism | 22 | 1 | 0.27 | 0.0016 |
| Lysine degradation | 25 | 1 | 0.30 | 0.14 |
| Glycolysis or Gluconeogenesis | 26 | 1 | 0.31 | 0.0 |
| Folate biosynthesis | 27 | 1 | 0.32 | 0.0 |
| Arginine and proline metabolism | 38 | 1 | 0.42 | 0.056 |
| Tryptophan metabolism | 41 | 1 | 0.45 | 0.0 |
| Purine metabolism | 65 | 1 | 0.61 | 0.0 |
Pathway impact values and p-values were obtained from metabolic pathway analysis performed with MetaboAnalyst 4.0 software. Pathways highlighted in bold were identified in the case of both serum and AH samples.