Table 4.
Association between the MTNR1B-rs10830963 polymorphism and type-2 diabetes risk in replication cohort 1.
| Strata | Genotypes (%) | |||||
|---|---|---|---|---|---|---|
| CC | CG | GG | ||||
| Non-diabetic subjects | 52.3 | 40.8 | 6.9 | |||
| Type-2 diabetic subjects | 47.8 | 41.6 | 10.6 | OR and 95% CI | p | |
| ptrend: 0.046 | Model 1: | 1.22 (1.03–1.48) | 0.046 | |||
| Model 2: | 1.22 (1.01–1.49) | 0.046 | ||||
| Model 3: | 1.22 (1.03–1.48) | 0.048 | ||||
MTNR1B: melatonin receptor 1B gene; CC, CG and GG are the MTNR1B-rs10830963 genotypes. OR: Odds ratio; CI: Confidence interval. Genotype prevalence by diabetes status is presented in % for 537 non-diabetic subjects and 464 type-2 diabetic subjects. Logistic regression models were used. Unadjusted p-value for the trend in genotype comparisons is shown. In addition, ORs and 95%Cis for type-2 diabetes risk associated with the MTNR1B-rs10830963 polymorphism are included. An additive genetic model was considered and the OR indicates the risk per G-allele. Model 1: Unadjusted. Model 2: Adjusted for sex and age. Model 3: Adjusted for sex, age, and obesity.