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. 2020 Nov 26;10:20622. doi: 10.1038/s41598-020-77674-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Alteration of Biological processes by cannabidiol (CBD) treatment. (A) The significant gene ontology terms of associated biological processes from differentially up-and down-regulated genes in CBD-treated FaDu cells were listed (twofold difference with p < 0.05). (B) The list showed the DNA damage- and cell cycle arrest-related genes in RNA-seq data. (C) The expression levels of down-regulated genes encoding MCM2, PARP1, and BRCA1 were confirmed by quantitative real-time RT-PCR and compared with the results of RNA-seq.