Table 1.
Clinical and demographic characteristics of participants.
| HC (n = 25) | IBS-D (n = 43) | P value | |
|---|---|---|---|
| Gender, F:M | 11:14 | 30:13 | 0.036* |
| Age, years | 35 (30–39) | 37 (34–41) | 0.242 |
| Atopy, yes: no | 6:14 | 20:18 | 0.253 |
| Intensity of abdominal pain, score | 0 | 47.69 ± 24.54 | – |
| Frequency of abdominal pain, score | 0 | 5.48 (3–10) | – |
| Bowel movements (n) | 1 (1–2) | 4 (1–12) | < 0.0001** |
| Stool form, Bristol score | 3.3 (2–5) | 5.5 (2–7) | < 0.0001** |
| Dyspepsia | – | 23/43 | |
| Distention | – | 47.5 (0–100) | – |
| Holmes-Rahe Scale | 116 (29–267) | 179 (25–889) | 0.237 |
| Cohen Scale | 16 (4–28) | 25 (9–46) | < 0.0001** |
| Beck’s Depression Index | 3 (0–22) | 11 (0–36) | < 0.0001** |
Values represent the median (range) or the mean ± SD. P Values considered significant are shown in bold. P value adjusted (false discovery rate): *P < 0.05; **P < 0.001. F, female; M, male; HC, healthy controls; IBS-D, diarrhea-predominant IBS.