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. 2020 Nov 26;10:20615. doi: 10.1038/s41598-020-77699-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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MMP1 interdomain dynamics as a two-state system. (A) Examples of simulated smFRET trajectories with noise for active MMP1 (blue) and active site mutant of MMP1 (orange) using experimentally-determined parameters for MMP1 without tetracycline. (B) Area-normalized histograms of simulated smFRET values with best fits to a sum of two Gaussians (solid black line). (C) Autocorrelations of simulated smFRET trajectories with best fits to exponentials (active: dashed black line; active site mutant: solid black line). As expected, power law did not fit autocorrelations (active: dashed red line; active site mutant: solid green line). k1 + k2 was recovered from exponential fits with and without noise. The error bars are the standard errors of mean for histograms and autocorrelations and are too small to be seen.