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. 2020 Nov 26;10:20703. doi: 10.1038/s41598-020-77656-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Different protein distribution patterns by cBM-MSCs and cDPSCs upon an in vitro osteogenic differentiation as assessed by Volcano plots. Schematic diagram of an in vitro osteogenic induction and the comparative proteomics-based systems biology analysis of the osteogenic differentiation behavior was showed (A). Volcano plots (n = 5) reflecting the distribution of expressed proteins by osteogenic cBM-MSCs and cDPSCs at day 7 and 14 post-induction were illustrated (B). The results were represented as − log p value and fold change (upregulation and downregulation). Red lines indicated p value < 0.05. Proteins located above the red line were significantly different compared with undifferentiated control (day 0).