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. 2020 Nov 26;10:20703. doi: 10.1038/s41598-020-77656-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Different protein clustering patterns by cBM-MSCs and cDPSCs upon an in vitro osteogenic differentiation as assessed by heatmaps and Four-Circle Venn Diagram. Heatmaps with Dendrogram (n = 5) were illustrated for showing the clustering of significant expressed proteins by cBM-MSCs and cDPSCs upon an in vitro osteogenic differentiation at day 7 and 14 post-induction (n = 5). Color scale represents fold-change of protein upregulation (red) or downregulation (blue) (A). Four-Circle Venn Diagram (n = 5) illustrated the number of unique or overlapping proteins significantly expressed by cBM-MSCs and/or cDPSCs upon an in vitro osteogenic differentiation at day 7 and 14 post-induction (B).