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. 2020 Nov 26;10:20703. doi: 10.1038/s41598-020-77656-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Tree diagram-based comprehensive analysis and pathway summary of selected potential signaling regulating osteogenic differentiation by cBM-MSCs and cDPSCs in vitro. For comprehensive understanding on signaling dynamic, tree diagram analysis of functional validated signaling was performed by tracking protein relationship at 3 timepoints during osteogenic differentiation (day 7 vs. 0, day 14 vs. 0, and day 14 vs. 7), comprising Wnt signaling pathway (A), Notch signaling pathway (B), and BMP-related signaling pathways (C). The diagrams illustrated dynamic changing of signaling components in cBM-MSCs (green box) and cDPSCs (pink box), while tree diagram connectors represented significant protein upregulation or downregulation by red or blue code, respectively. Yellow code represented unchanged protein level. All episodes were coded as #1 to #27. Numbers in the brackets referred to total protein numbers respectively expressed by osteogenic cBM-MSCs and cDPSCs in each episode. Summary of unique signaling relationship on osteogenic differentiation by cBM-MSCs and cDPSCs was illustrated (D).