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. 2020 Nov 4;9(11):1081. doi: 10.3390/antiox9111081

Figure 1.

Figure 1

(a) Effect of the sigma-1 receptor (σ1R) ligands on the severity of inflammation in 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis. Representative images of the colonic damage: (b) absolute control (no treatment); (c) 50% ethanol (EtOH enema); (d) TNBS enema; (e) TNBS enema + 1 mg/kg fluvoxamine (FLV); (f) TNBS enema + 0.1 mg/kg BD1063; (g) TNBS enema + 1 mg/kg FLV + 0.1 mg/kg BD1063; (h) TNBS enema + Saline; (i) TNBS enema + 3% DMSO. Data representation: mean ± SEM; n = 5–12/group; *** p < 0.001 TNBS vs. TNBS + treatment; ### p < 0.001 absolute control vs. TNBS; &&& p < 0.001 EtOH vs. TNBS.