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NUC-1031 overcomes the main resistance mechanisms associated with gemcitabine, in particular, transport via human equilibrative nucleoside transporters (hENT1), breakdown via cytidine deaminase (CDA), and activation via deoxycytidine kinase (dCK). NUC-1031 is designed to create and retain higher drug levels concentrations of metabolite inside the tumor in comparison to gemcitabine. The promoieties are shown with a dashed red line.
