Table 1.

Classification of human classical Ehlers–Danlos syndrome (cEDS).

Inheritance	Autosomal dominant
Molecular Basis	COL5A1; COL5A2; COL1A1; COL3A1
Major Criteria	1. Skin hyperextensibility and atrophic scarring
	2. Generalized joint hypermobility
Minor Criteria	1. Easy bruising
	2. Soft, doughy skin
	3. Skin fragility (or traumatic splitting)
	4. Molluscoid pseudotumors
	5. Subcutaneous spheroids
	6. Hernia
	7. Epicanthal folds
	8. Complications of joint hypermobility
	9. Family history of first-degree relative who meets clinical criteria

Adapted from Malfait et al. 2017 [2].