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. 2020 Oct 24;9(11):879. doi: 10.3390/pathogens9110879

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Ischemic pre (IPC)- and post-conditioning (IPO) induce upregulation of trained immunity regulators more than liver IRI. A database mining work (GSE24430) of rat liver ischemia-reperfusion with trained immunity pathway (TIP) enzymes. (A) The detailed description of group classification and a summary of TIP enzyme gene changes (up-/downregulation) in each group. (B) The Venn-diagram results of up- or downregulation genes that are shown in A. (C) The details of overlapped gene groups, gene names, and fold changes (Log2FC) of each gene. p value < 0.05. Glycolysis, acetyl-CoA, mevalonate pathway enzymes were marked in black, orange, and green, respectively. (D) We used the GENEONTOLOGY website (http://geneontology.org/) to analyze four groups (IRI, IPC, IPO, IPC+IPO) of TIP genes in C and found the top five-fold enrichment pathways that are related to each of the group entities. (E) The Venn-diagram of four group pathways. (F) The overlapped pathway among the four groups mentioned above. The total gene list of each group can be found in Supplementary Table S6.