Figure 8.

Casp DKO mice exhibit decreased cell death following ischemia-reperfusion. (A) Casp DKO and WT mice were both subjected to IRI and cell death was measured by the TUNEL assay. Casp DKO (a) and WT Sham (b) control groups had no TUNEL+ apoptotic/pyroptotic cells present. However, WT mice undergoing IR had increased TUNEL+ apoptotic/pyroptotic cells while Casp DKO mice had no TUNEL+ cells (d). (Magnification ×40). Red arrows indicated TUNEL+ apoptotic cells. (B) Quantification of TUNEL assay. Mean and standard deviation are shown. n = 6 per group.