Table 1.
Description of Lynch syndrome (LS) and control families.
| LS Families (N = 24) | Control Families (N = 10) | |||||||
|---|---|---|---|---|---|---|---|---|
| MMR Mutation-Carriers (N = 60) |
Non-Carriers (N = 31) |
Controls (N = 37) |
||||||
| Cancer | Cancer-free | Cancer | Cancer-free | Total 91 |
Cancer | Cancer-free | Total 37 |
|
| n | 32 | 28 | 2 | 29 | 3 | 34 | ||
| Parent: N (%) | 24 (75) | b 3 (11) | 2 (100) | c 15 (52) | 44 (48) | 3 (100) | 15 (44) | 18 (49) |
| Children: N (%) | 8 (25) | 25 (89) | 0 (0) | 14 (48) | 47 (52) | 0 (0) | 19 (56) | 19 (51) |
| MSH2+/−: N (%) | 15 (47) | 18 (64) | - | - | 33 (36) | - | - | |
| MLH1+/−: N (%) | 17 (53) | 10 (36) | - | - | 27 (30) | - | - | |
| a MMR+/+: N (%) | - | - | 2 (100) | 29 (100) | 31 (34) | 3 (100) | 34 (100) | 37 (100) |
| Sex: N (%) | F: 14 (44) | F: 17 (61) | F: 2 (100) | F: 16 (55) | F: 49 (54) | F: 2 (67) | F: 21 (62) | 23 (62) |
| M: 18 (56) | M: 11 (39) | M: 0 (0) | M: 13 (45) | M: 42 (46) | M: 1 (33) | M: 13 (38) | 14 (38) | |
| Mean age at sample ±SD parents | 60 ± 8 | 66 ± 2 | 65 ± 11 | 63 ± 7 | 62 ± 8 | 56 ± 3 | 62 ± 10 | 61 ± 10 |
| Mean age at sample ±SD children | 35 ± 8 | 33 ± 7 | - | 35 ± 8 | 34 ± 7 | - | 31 ± 11 | 31 ± 11 |
| Mean age 1st cancer ±SD parents | 45 ± 11 | - | 59 ± 9 | - | - | 44 ± 8 | - | - |
| Mean age 1st cancer ±SD children | 24 ± 7 | - | - | - | - | - | - | - |
Abbreviations: n: number of families or individuals; N (%): number of subjects and percentage within a group; a MMR+/+: homozygous for a wild type MMR gene; F: female; M: male. SD: standard deviation; b One MSH2+/− individual in a three generation LS family was treated as child and as parent. c 15 MMR+/+ parents in the LS families were included as controls in age versus telomere length graphs (total controls = 52).