Table 1.
Ratios (mean ± SD) of anti-inflammatory to proinflammatory cytokines showing significant differences between endometrial explants of blastocyst-bearing (BB) and uninseminated cyclic (U-IC) sows.
| Anti-/Proinflammatory Cytokine | Cytokine Ratio 1 | Fold Increase 2 | p-Value | |
|---|---|---|---|---|
| BB Sows | U-IC Sows | |||
| IL-1ra/IL-1α | 452.7 ± 299.6 | 182.7 ± 38.0 | 2.5 | p < 0.001 |
| IL-1ra/IL-1β | 18.1 ± 14.2 | 4.0 ± 2.2 | 4.5 | p < 0.001 |
| IL-1ra/IL-8 | 2.6 ± 2.1 | 0.5 ± 0.2 | 4.8 | p < 0.001 |
| IL-1ra/IL-18 | 14.7 ± 12.6 | 3.2 ± 2.0 | 4.6 | p < 0.001 |
| IL-1ra/GM-CSF | 312.6 ± 205.7 | 43.4 ± 22.4 | 7.2 | p < 0.001 |
| IL-6/IL-1β | 14.7 ± 6.2 | 6.6 ± 3.1 | 2.2 | p < 0.001 |
| IL-6/IL-8 | 2.0 ± 0.7 | 0.9 ± 0.3 | 2.3 | p < 0.001 |
| IL-6/IL-18 | 11. 6 ± 4.4 | 6.0 ± 4.4 | 1.9 | p < 0.001 |
| IL-6/GM-CSF | 276.6 ± 101.2 | 70. 6 ± 30.0 | 3.9 | p < 0.001 |
| IL-10/IL-1β | 0.1 ± 0.05 | 0.05 ± 0.02 | 1.9 | p < 0.01 |
| IL-10/IL-2 | 0.4 ± 0.1 | 0. 6 ± 0.2 | 0.7 | p < 0.01 |
| IL-10/IL-8 | 0.01 ± 0.01 | 0.006 ± 0.003 | 1.9 | p < 0.01 |
| IL-10/IL-18 | 0.1 ± 0.02 | 0.03 ± 0.02 | 1.8 | p < 0.001 |
| IL-10/GM-CSF | 1.5 ± 0.4 | 0.5 ± 0.2 | 3.3 | p < 0.001 |
| IL-10/IFNγ | 0.01 ± 0.01 | 0.02 ± 0.01 | 0.6 | p < 0.001 |
| TGFβ1/IL-2 | 1.7 ± 0.6 | 3.3 ± 1.7 | 0.5 | p < 0.001 |
| TGFβ1/IL-8 | 0.05 ± 0.02 | 0.03 ± 0.01 | 1.5 | p < 0.05 |
| TGFβ1/IL-18 | 0.3 ± 0.2 | 0.2 ± 0.1 | 1.6 | p < 0.05 |
| TGFβ1/GM-CSF | 6.3 ± 2.5 | 2.4 ± 0.7 | 2.7 | p < 0.001 |
| TGFβ1/IFNγ | 0.04 ± 0.01 | 0.1 ± 0.1 | 0.4 | p < 0.001 |
| TGFβ2/IL-1β | 1.0 ± 0.8 | 0.7 ± 0. 6 | 1.4 | p < 0.05 |
| TGFβ2/IL-2 | 4.5 ± 1.9 | 9.3 ± 5.8 | 0.5 | p < 0.01 |
| TGFβ2/IL-18 | 0.7 ± 0.3 | 0.4 ± 0.2 | 1.5 | p < 0.05 |
| TGFβ2/GM-CSF | 16.2 ± 8.0 | 6.3 ± 2.5 | 2.6 | p < 0.001 |
| TGFβ2/IFNγ | 0.1 ± 0.03 | 0.3 ± 0.2 | 0.4 | p < 0.001 |
1 The anti-/proinflammatory ratio was calculated by dividing the levels of anti-inflammatory cytokines by the proinflammatory cytokines. Green and red indicate a shift towards an anti-inflammatory or proinflammatory profile, respectively. 2 Bold values indicate the fold increase of the anti-inflammatory ratio in BB sows compared to U-IC sows.