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. 2020 Oct 30;9(11):2377. doi: 10.3390/cells9112377

Figure 3.

Figure 3

Anti-SARS-CoV-2 effects of aprotinin when administered post-infection. For post-infection experiments, the cells were incubated with the virus for a one-hour adsorption period. Then, the cells were washed three times in PBS prior to the addition of the drug. (A) The effects of aprotinin and the RNA polymerase inhibitor remdesivir (a positive control drug that interferes with virus replication after virus entry) on virus replication as determined by qPCR in SARS-CoV-2/FFM1 (MOI of 0.1)-infected Caco2 cells 8 h post-infection (after approximately one round of replication). * p < 0.05 as determined by one-way ANOVA and Dunnett’s multiple comparison test. (B) The effects of aprotinin on cytopathogenic effect (CPE) formation in SARS-CoV-2/FFM1 (MOI of 0.01)-infected Caco2 cells were determined 48 h post-infection.