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. 2020 Oct 30;9(11):2377. doi: 10.3390/cells9112377

Figure 4.

Figure 4

Regulation of host cell protease inhibitors in SARS-CoV-2-infected cells. (A) Total protein levels based on a publicly available proteomics dataset [35], indicating cellular levels of endogenous protease inhibitors in SARS-CoV-2 (MOI of 1)-infected Caco2 cells 2 h and 24 h post-infection. Data were normalized using summed intensity normalization for sample loading, followed by internal reference scaling and trimmed mean of M normalization. * p-values as determined using a two-sided Student’s t-test. (B) Mean protein translation of endogenous protease inhibitors in arbitrary units (AU) (normalized and corrected summed peptide spectrum matches (PSMs) were averaged) in SARS-CoV-2 (MOI of 1)-infected Caco2 cells 2 h and 24 h post-infection based on a publicly available translatome dataset [35]. * p-values as determined using a two-sided Student’s t-test.