Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Aprotinin concentrations that reduce SARS-CoV-2-induced cytopathogenic effect (CPE) formation, SARS-CoV-2 spike (S) levels, and SARS-CoV-2-induced caspase 3/7 activation by 50% (IC50) as determined in Caco2 cells infected with different SARS-CoV-2 isolates (MOI of 0.01) 48 h post-infection.
| IC50 (µM) | |||
|---|---|---|---|
| FFM1 | FFM2 | FFM6 | |
| CPE formation | 1.03 ± 0.07 | 0.81 ± 0.07 | 0.92 ± 0.03 |
| S levels | 0.79 ± 0.15 | 1.04 ± 0.21 | 1.65 ± 0.30 |
| Caspase 3/7 activation | 0.41 ± 0.25 | 0.32 ± 0.09 | 0.73 ± 0.40 |
