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The cytotoxicity of single drug (CPT-11 or panobinostat) (A) and dual drug (CPT-11 and panobinostat) (B) toward U87DR at different time points (n = 5). (C) The synergistic effect of drug combination was analyzed by CompuSyn software with results taken from (B), from which the combination index (CI) value could be used to categorize the drug interaction into synergism (CI < 1), additive (CI = 1) and antagonism (CI > 1).
