Figure 6.

AIE impairs novel object recognition (NOR) in middle age female rats. (a) Timeline for NOR. Rats underwent AIE or CON gavage paradigms from PND 25–54. The NOR test was conducted later in adulthood (9 months of age). Males were tested first, followed by females. (b) Even in middle age, female rats that were exposed to AIE more than 7 months prior continue to show cognitive deficits, as evidenced by lack of discrimination in the percentage of time spent between novel and familiar objects. Results are expressed as mean ± SEM. * p < 0.05.