Table 2.
Event | Population | Exposure | MS cases | Controls | OR (95% CI) | P value | P value for interaction |
---|---|---|---|---|---|---|---|
Cluster 1: Death of a close friend or relative | Overall | No event | 1555 (0.70) | 2951 (0.69) | 1.00 ref | ||
Any event | 661 (0.30) | 1351 (0.31) | 0.90 (0.80–1.01) | 0.08 | 0.89 | ||
Female | No event | 1113 (0.7) | 2085 (0.68) | 1.00 ref | |||
Any event | 479 (0.3) | 975 (0.32) | 0.89 (0.78–1.02) | 0.10 | NA | ||
Male | No event | 442 (0.71) | 866 (0.7) | 1.00 ref | |||
Any event | 182 (0.29) | 376 (0.3) | 0.90 (0.72–1.13) | 0.36 | NA | ||
Cluster 2: Sickness, accident or death of a spouse, partner or child | Overall | No event | 2255 (0.88) | 4792 (0.91) | 1.00 ref | ||
Any event | 302 (0.12) | 503 (0.09) | 1.26 (1.08–1.47) | 0.007 | 0.06 | ||
Female | No event | 1578 (0.87) | 3360 (0.9) | 1.00 ref | |||
Any event | 239 (0.13) | 373 (0.1) | 1.37 (1.14–1.63) | 0.001 | NA | ||
Male | No event | 677 (0.91) | 1432 (0.92) | 1.00 ref | |||
Any event | 63 (0.09) | 130 (0.08) | 0.98 (0.70–1.36) | 0.90 | NA | ||
Cluster 3: Serious conflict with a spouse or partner, divorce, marriage | Overall | No event | 1191 (0.52) | 2515 (0.56) | 1.00 ref | ||
Any event | 1105 (0.48) | 1989 (0.44) | 1.14 (1.03–1.27) | 0.014 | 0.61 | ||
Female | No event | 823 (0.5) | 1753 (0.54) | 1.00 ref | |||
Any event | 822 (0.5) | 1480 (0.46) | 1.16 (1.03–1.32) | 0.018 | NA | ||
Male | No event | 368 (0.57) | 762 (0.6) | 1.00 ref | |||
Any event | 283 (0.43) | 509 (0.4) | 1.09 (0.89–1.34) | 0.39 | NA | ||
Cluster 4: Conflict at work, conflict with a close relative or friend, unemployment, poor economy | Overall | No event | 1188 (0.56) | 2561 (0.61) | 1.00 ref | ||
Any event | 921 (0.44) | 1637 (0.39) | 1.16 (1.04–1.30) | 0.007 | 0.81 | ||
Female | No event | 791 (0.53) | 1699 (0.57) | 1.00 ref | |||
Any event | 711 (0.47) | 1269 (0.43) | 1.15 (1.01–1.31) | 0.032 | NA | ||
Male | No event | 397 (0.65) | 862 (0.7) | 1.00 ref | |||
Any event | 210 (0.35) | 368 (0.3) | 1.19 (0.96–1.47) | 0.12 | NA |
CI, confidence interval; OR, odds ratio.
Results adjusted for age, sex (for overall population), residential area, pack‐years of smoking, alcohol consumption in grams, levels of education. P values for interaction present P values for the event‐by‐sex interaction calculated in the overall population by adding an interaction term to the logistic model. Bold values indicate results with statistical significance, that is, a P‐value <0.05