Table 3.
The association between each component event and risk of multiple sclerosis, stratified by sex
| Cluster | Component event | Population | Exposure | MS cases | Controls | OR (95% CI) | P value | P value for interaction |
|---|---|---|---|---|---|---|---|---|
| Cluster 2 | Sickness or accident of a spouse, partner or child | Overall | No event | 2278 (0.89) | 4843 (0.91) | 1.00 ref | 0.007 | 0.02 |
| Any event | 286 (0.11) | 480 (0.09) | 1.25 (1.06–1.46) | |||||
| Female | No event | 1593 (0.87) | 3405 (0.91) | 1.00 ref | 0.001 | NA | ||
| Any event | 229 (0.13) | 354 (0.09) | 1.38 (1.15–1.65) | |||||
| Male | No event | 685 (0.92) | 1438 (0.92) | 1.00 ref | 0.53 | NA | ||
| Any event | 57 (0.08) | 126 (0.08) | 0.90 (0.63–1.26) | |||||
| Death of a spouse, partner or child | Overall | No event | 2864 (0.99) | 5998 (0.99) | 1.00 ref | 0.24 | 0.17 | |
| Any event | 24 (0.01) | 40 (0.01) | 1.36 (0.82–2.28) | |||||
| Female | No event | 2053 (0.99) | 4266 (0.99) | 1.00 ref | 0.83 | NA | ||
| Any event | 15 (0.01) | 32 (0.01) | 1.07 (0.58–1.99) | |||||
| Male | No event | 811 (0.99) | 1732 (1.00) | 1.00 ref | 0.051 | NA | ||
| Any event | 9 (0.01) | 8 (0.00) | 2.67 (1.00–7.13) | |||||
| Cluster 3 | Serious conflict with a spouse or partner | Overall | No event | 1974 (0.78) | 4135 (0.81) | 1.00 ref | 0.007 | 0.91 |
| Any event | 543 (0.22) | 939 (0.19) | 1.18 (1.05–1.34) | |||||
| Female | No event | 1376 (0.77) | 2887 (0.80) | 1.00 ref | 0.017 | NA | ||
| Any event | 413 (0.23) | 717 (0.20) | 1.19 (1.03–1.37) | |||||
| Male | No event | 598 (0.82) | 1248 (0.85) | 1.00 ref | 0.21 | NA | ||
| Any event | 130 (0.18) | 222 (0.15) | 1.17 (0.91–1.50) | |||||
| Divorce or equivalent | Overall | No event | 2221 (0.84) | 4805 (0.87) | 1.00 ref | 0.0003 | 0.85 | |
| Any event | 417 (0.16) | 691 (0.13) | 1.28 (1.12–1.47) | |||||
| Female | No event | 1558 (0.83) | 3376 (0.86) | 1.00 ref | 0.001 | NA | ||
| Any event | 322 (0.17) | 533 (0.14) | 1.29 (1.10–1.50) | |||||
| Male | No event | 663 (0.87) | 1429 (0.90) | 1.00 ref | 0.15 | NA | ||
| Any event | 95 (0.13) | 158 (0.10) | 1.23 (0.93–1.63) | |||||
| Marriage or equivalent | Overall | No event | 1628 (0.68) | 3441 (0.72) | 1.00 ref | 0.005 | 0.16 | |
| Any event | 761 (0.32) | 1344 (0.28) | 1.17 (1.05–1.31) | |||||
| Female | No event | 1147 (0.67) | 2452 (0.71) | 1.00 ref | 0.002 | NA | ||
| Any event | 567 (0.33) | 978 (0.29) | 1.23 (1.08–1.41) | |||||
| Male | No event | 481 (0.71) | 989 (0.73) | 1.00 ref | 0.78 | NA | ||
| Any event | 194 (0.29) | 366 (0.27) | 1.03 (0.83–1.28) | |||||
| Cluster 4 | Serious conflict with a close relative or friend | Overall | No event | 2176 (0.85) | 4634 (0.88) | 1.00 ref | 0.005 | 0.87 |
| Any event | 374 (0.15) | 614 (0.12) | 1.23 (1.07–1.42) | |||||
| Female | No event | 1490 (0.83) | 3179 (0.86) | 1.00 ref | 0.009 | NA | ||
| Any event | 310 (0.17) | 506 (0.14) | 1.23 (1.05–1.45) | |||||
| Male | No event | 686 (0.91) | 1455 (0.93) | 1.00 ref | 0.27 | NA | ||
| Any event | 64 (0.09) | 108 (0.07) | 1.21 (0.86–1.69) | |||||
| Poor economy | Overall | No event | 2115 (0.86) | 4529 (0.88) | 1.00 ref | 0.018 | 0.53 | |
| Any event | 346 (0.14) | 598 (0.12) | 1.19 (1.03–1.38) | |||||
| Female | No event | 1484 (0.85) | 3174 (0.87) | 1.00 ref | 0.079 | NA | ||
| Any event | 255 (0.15) | 458 (0.13) | 1.16 (0.98–1.38) | |||||
| Male | No event | 631 (0.87) | 1355 (0.91) | 1.00 ref | 0.12 | NA | ||
| Any event | 91 (0.13) | 140 (0.09) | 1.26 (0.94–1.69) | |||||
| Conflict at work | Overall | No event | 2125 (0.86) | 4461 (0.89) | 1.00 ref | 0.001 | 0.42 | |
| Any event | 349 (0.14) | 565 (0.11) | 1.30 (1.12–1.50) | |||||
| Female | No event | 1489 (0.84) | 3135 (0.88) | 1.00 ref | 0.001 | NA | ||
| Any event | 274 (0.16) | 430 (0.12) | 1.33 (1.12–1.57) | |||||
| Male | No event | 636 (0.89) | 1326 (0.91) | 1.00 ref | 0.26 | NA | ||
| Any event | 75 (0.11) | 135 (0.09) | 1.19 (0.88–1.63) | |||||
| Unemployed | Overall | No event | 2242 (0.88) | 4733 (0.89) | 1.00 ref | 0.17 | 0.98 | |
| Any event | 313 (0.12) | 579 (0.11) | 1.11 (0.96–1.29) | |||||
| Female | No event | 1599 (0.88) | 3371 (0.89) | 1.00 ref | 0.27 | NA | ||
| Any event | 224 (0.12) | 418 (0.11) | 1.10 (0.93–1.32) | |||||
| Male | No event | 643 (0.88) | 1362 (0.89) | 1.00 ref | 0.46 | NA | ||
| Any event | 89 (0.12) | 161 (0.11) | 1.11 (0.84–1.49) |
CI, confidence interval; OR, odds ratio.
Results adjusted for age, sex (for overall population), residential area, pack‐years of smoking, alcohol consumption in grams, levels of education. P values for interaction present P values for the event‐by‐sex interaction calculated in the overall population by adding an interaction term to the logistic model. Bold values indicate results with statistical significance, that is, a P‐value <0.05