Table 3.

Case Reports of Methimazole- or Carbimazole-Induced Acute Pancreatitis

Authors	Reporting year	Ethnicity	Age	Sex	Diagnosis	Time of symptom onset	Drug	Dose (mg)	Management
Taguchi et al. (3)	1999	Japanese	66	W	Graves' disease	21 days 3 hours after 2nd dose	MMI	30 10a	PTU
Marazuela et al. (4)	2002	Spanish	33	W	Graves' disease	30 days 1 day	Carbimazole	45 10a	RAI
Su et al. (5)	2008	Chinese	19	W	Graves' disease	75 days	MMI	10	RAI
Chng et al. (6)	2011	Asian	70	W	Graves' disease	14 days	Carbimazole	30	RAI
Abraham et al. (7)	2012	Caucasian	80	W	Unspecified	90 days	MMI	10	Unspecified
Yang et al. (8)	2012	Chinese	18	W	Graves' disease	4 days Within 1 day	MMI	20 10b 10b 10b	PTU
Jung et al. (9)	2014	Korean	51	M	Graves' disease	14 days 5 hours	MMI	20 10a	Unspecified
Agito et al. (10)	2015	Caucasian	51	W	Toxic MNG	21 days 5 days	MMI	10 10a	RAI
Kikuchi et al. (11)	2018	Japanese	76	W	Graves' disease	19 days	MMI	10	Potassium iodide

There is no report of recurrent rate of acute pancreatitis in patients who were not re-exposed to thionamides.

^aRechallenged.

^bRechallenged three times at different times by three physicians.

M, men; MMI, methimazole; MNG, multinodular goiter; PTU, propylthiouracil; RAI, radioactive iodine; W, women.