Table 1.
Baseline Population Characteristics.
| Patient Characteristics | All | PXE Patients | Healthy Volunteers | p |
|---|---|---|---|---|
| Age | 46 | 23 | 23 | 0.79 |
| (mean ± sd) | 46.67 ± 13.53 | 47.22 ± 14.10 | 46.13 ± 13.23 | |
| Sex | 46 | 23 | 23 | 1.00 |
| Female | 24 (52.2%) | 12 (52.2%) | 12 (52.2%) | |
| Male | 22 (47.8%) | 11 (47.8%) | 11 (47.8%) | |
| BMI (Kg/m2) | 44 | 23 | 21 | 0.20 |
| (median (IQR)) | 23.57 (22.23;26.54) | 24.01 (22.68;28.41) | 23.24 (21.07;25.68) | |
| SBP (mmHg) | 40 | 23 | 17 | 0.15 |
| (median (IQR)) | 120.50 (112.50;131.50) | 121.00 (114.00;142.00) | 118.00 (110.00;126.00) | |
| DBP (mmHg) | 40 | 23 | 17 | 0.60 |
| (median (IQR)) | 70.00 (63.00;74.50) | 69.00 (63.00;78.00) | 71.00 (66.00;73.00) | |
| Right ABI | 40 | 23 | 17 | 0.10 |
| (mean ± sd) | 1.02 ± 0.18 | 0.98 ± 0.20 | 1.07 ± 0.14 | |
| Left ABI | 40 | 23 | 17 | 0.16 |
| (mean ± sd) | 1.02 ± 0.20 | 0.98 ± 0.23 | 1.07 ± 0.13 | |
| Total Cholesterol (mmol/L) | 39 | 23 | 16 | 0.80 |
| (mean ± sd) | 5.20 ± 1.01 | 5.24 ± 0.95 | 5.16 ± 1.12 | |
| LDL Cholesterol (mmol/L) | 38 | 23 | 15 | 0.84 |
| (mean ± sd) | 3.21 ± 0.87 | 3.23 ± 0.89 | 3.17 ± 0.86 | |
| HbA1c % | 31 | 20 | 11 | 0.76 |
| (mean ± sd) | 5.44 ± 0.45 | 5.42 ± 0.51 | 5.47 ± 0.33 | |
| hsCRP (mg/L) | 46 | 23 | 23 | 0.49 |
| 1.74 ± 2.70 | 2.11 ± 3.45 | 1.37 ± 1.67 | ||
| PPi (μmol/L) | 17 | 17 | ||
| Only for PXE patients | 7.00E-07 ± 6.00E-07 | 7.00E-07 ± 6.00E-07 | ||
| Current Smoker | 46 | 23 | 23 | 0.02 |
| No | 40 (87.0%) | 17 (73.9%) | 23 (100.0%) | |
| Yes | 6 (13.0%) | 6 (26.1%) | 0 (0.0%) | |
| Stroke | 46 | 23 | 23 | 1.00 |
| No | 45 (97.8%) | 22 (95.7%) | 23 (100.0%) | |
| Yes | 1 (2.2%) | 1 (4.3%) | 0 (0.0%) | |
| Myocardial Infarction | 46 | 23 | 23 | 1.00 |
| No | 45 (97.8%) | 22 (95.7%) | 23 (100.0%) | |
| Yes | 1 (2.2%) | 1 (4.3%) | 0 (0.0%) | |
| PAD | 46 | 23 | 23 | 0.002 |
| No | 37 (80.4%) | 14 (60.9%) | 23 (100.0%) | |
| Yes | 9 (19.6%) | 9 (39.1%) | 0 (0.0%) |
BMI: Body Mass Index; ABI: Ankle-Brachial Index; SBP: Systolic Blood Pressure; DBP: Diastolic Blood Pressure; PAD: Peripheral Arterial Disease; sd: Standard Deviation; IQR: Interquartile Range; LDL: Low Density Cholesterol; HbA1c: Glycated Hemoglobin; PXE: Pseudoxanthoma Elasticum.