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. 2020 Oct 25;9(11):2352. doi: 10.3390/cells9112352

Figure 1.

Figure 1

Biosynthesis of cholesterol and its derivatives. Squalene synthase (FDFT1) is the critical enzyme for the synthesis of sterols, and ultimately cholesterol. This enzyme plays an essential role in directing intermediates to either sterol or nonsterol branches of this metabolic pathway [60,61].