Predicted phenotypic resistance (Stanford scores) for antiretroviral drugs currently recommended as first line therapy in Portugal (A) for ART-NP (2003–2017) and (B) for ART-EP (2003–2017). Scores of low-level (score 2 and 3), intermediate level (score 4) or high-level (score 5) resistance were used to predict phenotypic resistance. Abbreviations: NRTI, nucleoside reverse transcriptase inhibitors; NNRTI, non-nucleoside reverse transcriptase inhibitors; PI, protease inhibitors; FTC, emtricitabine; TDF, tenofovir; 3TC, lamivudine; ABC, abacavir; EFV, efavirenz; RPV, rilpivirine; DRV/r, darunavir; LPV/r, lopinavir; ATV/r, atazanavir; ART-NP, antiretroviral-naïve patients; ART-EP, antiretroviral-experienced patients.