IPT cohort					ITT cohort
	All (n = 54 066)	Combi mira/AM (n = 245)	OnabotulinumtoxinA (n = 244)	SNS (n = 188)	PTNS (n = 98)	All (n = 1662)	Combi mira/AM (n = 427)	OnabotulinumtoxinA (n = 456)	SNS (n = 535)	PTNS (n = 245)
Medications
Median (IQR)	322 (72, 1308)	5139 (2200, 7537)	885 (325, 2558)	725 (253, 1623)	1023 (390, 2973)	30 (0, 4253)	7467 (4626, 10 551)	0 (0, 462)	0 (0, 0)	81 (0, 1577)
Inpatient visits (hospitalizations)
Median (IQR)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
ER visits (inpatient and outpatient)
Median (IQR)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
Outpatient visits
Median (IQR)	74 (0, 297)	201 (114, 865)	3983 (2408, 7563)	30 371 (22 386, 47 374)	3861 (2651, 5481)	3696 (1088, 19 454)	329 (96, 895)	3702 (1928, 8026)	25 405 (8494, 38 262)	3724 (2336, 5802)
Physician visits, median (IQR)
GP	0 (0, 0)	0 (0, 0)	0 (0, 111)	0 (0, 82)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 4)	0 (0, 0)
Specialist	0 (0, 169)	114 (0, 201)	1821 (821, 3024)	3585 (1867, 5432)	3138 (1987, 4463)	1272 (206, 2766)	201 (0, 560)	1355 (423, 2906)	1761 (927, 3102)	2668 (1426, 4469)
Other	0 (0, 0)	0 (0, 89)	1899 (9, 4923)	26 946 (18 420, 42 880)	5 (0, 595)	713 (0, 15 586)	0 (0, 68)	1436 (0, 5748)	22 900 (4332, 35 266)	0 (0, 1544)
Procedures
Median (IQR)	0 (0, 0)	0 (0, 0)	972 (411, 2559)	5460 (1859, 19 346)	2239 (1750, 3467)	1549 (123, 4664)	0 (0, 0)	1250 (497, 3112)	4911 (1777, 19 374)	2780 (1775, 4706)
Total, median (IQR)	595 (185, 1982)	5564 (2519, 8073)	6479 (3877, 9906)	32 188 (23 190, 48 220)	5823 (3810, 7732)	7921 (3651, 20 846)	8097 (5608, 11 922)	4520 (2381, 9351)	26 057 (9978, 38 514)	5199 (2841, 8194)