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. 2020 Nov 11;21(1):31. doi: 10.3892/ol.2020.12292

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Copyright: © Yin et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Metformin inhibits the migration and invasion of oral squamous cell carcinoma cells. (A) Wound-healing assay was used to analyze the relative cell migration distance after 24 h (magnification, ×40) (B) Transwell assay was used to evaluate cell invasion (magnification, ×200). Metformin inhibited CoCl₂-induced EMT. *P<0.05; ***P<0.001; ^##P<0.01; ^###P<0.001 vs. control. (C-E) Expression levels of EMT markers were detected via reverse transcription-quantitative PCR. (C) E-cadherin, (D) vimentin and (E) Snail1. Data are presented as the mean value of cells in five fields based on three independent experiments. *P<0.05; **P<0.01; ***P<0.001. EMT, epithelial-mesenchymal transition; Snail1, snail family transcriptional repressor 1.