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. 2020 Nov 3;12(11):3237. doi: 10.3390/cancers12113237

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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A network of RNA regulators interacting with succinate dehydrogenase. Different proteins/processes affecting the transcription/translation of the SDH complex are shown. For example, the RNA-editing enzyme APOBEC3A decreases the expression of SDHB. Similarly, the non-coding RNAs miR-31 and miR-210 decrease SDHA and SDHD activity, respectively. It is important to note that the interplay between RNA-editing enzymes and RNA-modification genes with non-coding RNAs has been established, but the possible role of these regulators and their effect on SDH has yet to be discovered and warrants intrigue. Regulations are signified with inhibition (┤) and promotion (→) together with upregulation (red lettering) and downregulation (green lettering).