Table 2.
Baseline factors associated with liver-related deaths in all patients in univariate and multivariate Cox progression analyses.
| Factor | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-Value | HR | 95% CI | p-Value | |
| Age, years | ||||||
| ≤70 | 1 | |||||
| >70 | 1.065 | 0.873–1.30 | 0.533 | |||
| Gender | ||||||
| Male | 1 | |||||
| Female | 0.979 | 0.796–1.20 | 0.841 | |||
| Child–Pugh score | 1.48 | 1.41–1.56 | <0.001 | 1.37 | 1.29–1.47 | <0.001 |
| HCC stage | ||||||
| I | 1 | 1 | ||||
| II | 1.33 | 0.988–1.78 | <0.001 | 1.20 | 0.847–1.71 | 0.303 |
| III | 2.75 | 2.03–3.73 | <0.001 | 2.05 | 1.40–3.00 | <0.001 |
| IVa | 13.8 | 9.45–20.0 | <0.001 | 6.36 | 3.91–10.3 | <0.001 |
| IVb | 21.3 | 14.1–32.1 | <0.001 | 8.77 | 5.2–14.8 | <0.001 |
| AFP, ng/mL | ||||||
| ≤200 | 1 | 1 | ||||
| >200 | 2.90 | 2.33–3.60 | <0.001 | 1.36 | 1.05–1.77 | 0.019 |
| DCP, mAU/mL | ||||||
| ≤400 | 1 | 1 | ||||
| >400 | 3.01 | 2.47–3.66 | <0.001 | 1.58 | 1.22–2.05 | <0.001 |
| First treatment | ||||||
| Curative therapy | 1 | 1 | ||||
| TACE | 3.15 | 2.46–4.01 | <0.001 | 1.85 | 1.40–2.45 | <0.001 |
| Others | 28.7 | 20.2–40.8 | <0.001 | 4.24 | 2.70–6.66 | <0.001 |
| Antiplatelet therapy | ||||||
| Without | 1 | 1 | ||||
| With | 0.550 | 0.398–0.758 | <0.001 | 0.640 | 0.445–0.926 | 0.002 |
Abbreviations: AFP, alpha-fetoprotein; DCP, des-gamma-carboxy prothrombin; TACE, transcatheter arterial chemoembolization.