Table 4.
Baseline factors associated with Child–Pugh deterioration in patients with Child–Pugh grade A liver disease at baseline in univariate and multivariate Cox regression analyses.
| Factor | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-Value | HR | 95% CI | p-Value | |
| Age, years | ||||||
| ≤70 | 1 | 1 | ||||
| >70 | 1.32 | 1.04–1.67 | 0.023 | 1.69 | 1.29–2.20 | <0.001 |
| Gender | ||||||
| Male | 1 | |||||
| Female | 0.81 | 0.633–1.04 | 0.094 | |||
| Child–Pugh score | ||||||
| 5 | 1 | 1 | ||||
| 6 | 2.82 | 2.23–3.56 | <0.001 | 3.46 | 2.69–4.46 | <0.001 |
| HCC stage | ||||||
| I | 1 | 1 | ||||
| II | 1.15 | 0.834–1.58 | 0.396 | 0.784 | 0.555–1.11 | 0.169 |
| III | 2.26 | 1.60–3.18 | <0.001 | 1.36 | 0.925–1.99 | 0.119 |
| IVa | 12.1 | 7.56–19.3 | <0.001 | 4.56 | 2.61–7.98 | <0.001 |
| IVb | 13.3 | 7.78–22.8 | <0.001 | 5.93 | 3.02–11.7 | <0.001 |
| AFP, ng/mL | ||||||
| ≤200 | 1 | 1 | ||||
| >200 | 2.51 | 1.90–3.30 | <0.001 | 1.80 | 1.31–2.47 | <0.001 |
| DCP, mAU/mL | ||||||
| ≤400 | 1 | 1 | ||||
| >400 | 2.17 | 1.71–2.77 | <0.001 | 1.55 | 1.17–2.06 | <0.001 |
| First treatment | ||||||
| Curative therapy | 1 | 1 | ||||
| TACE | 2.54 | 1.99–3.26 | <0.001 | 1.77 | 1.34–2.36 | <0.001 |
| Others | 24.3 | 13.9–42.4 | <0.001 | 4.57 | 2.38–8.81 | <0.001 |
| Antiplatelet therapy | ||||||
| Without | 1 | 1 | ||||
| With | 0.524 | 0.369–0.746 | <0.001 | 0.467 | 0.321–0.679 | <0.001 |
Abbreviations: AFP, alpha-fetoprotein; DCP, des-gamma-carboxy prothrombin; TACE, transcatheter arterial chemoembolization.