FIGURE 3.

Composition of thrombi formed using the IVC stasis is F12^+/+ mice compared with F12 ^−/− mice and F11^+/+ mice compared with F11 ^−/− mice. Thrombus composition was assessed in thrombi from F12 ^−/− and F11 ^−/− mice formed using the IVC stasis model of thrombosis by western blotting of total soluble protein lysates and compared with respective wild‐type littermate controls. Densitometric analysis of immunoblots for (A, H) fibrin(ogen), (B, I) CD41, (C, J) Ly6G, (D, K) β actin, (E, L) citrullinated histone H3, and (F, M) total histone H3 for F12 ^−/−, F11 ^−/− mice and wild‐type littermate controls. (G, N) The ratio of H3Cit to total H3 was also calculated. *P < .01 Mann‐Whitney U test. Data represented as individual values plus the median