Table 1.
Comparative effects of FXII and FXI deficiency in mouse venous thrombosis models
| Approach | Model | Phenotype | Reference |
|---|---|---|---|
| ASO | St Thomas’ | Targeting FXII and FXI With High‐Level Knockdown Equally Protective | 16 |
| KO | IVC stenosis | FXII deficiency, but not FXI deficiency, protective | 17 |
| siRNA | FVEI | Targeting FXII more protective than FXI for intermediate level knockdown | 59 |
| KO | IVC stenosis | FXII and FXI deficiency equally protective |
Current study |
| KO | IVC stasis | FXII and FXI deficiency not protective |
Current study |
| KO | FVEI | FXII and FXI deficiency equally protective |
Current study |
Abbreviations: ASO, antisense oligonucleotide; FVEI, femoral vein electrolytic injury; IVC, inferior vena cava; KO, knockout; siRNA, short interfering RNA.