FIGURE 1.

Biotransformation of antiseizure drugs and their major CYPs and UGTs, including potential for drug‐drug interactions. 16 , 17 , 21 , 23 , 24 , 25 , 26 , 51 4‐ene‐VPA, 2‐propyl‐4‐pentenoic acid; 4′‐OH‐N‐CLB, 4′‐hydroxy‐N‐desmethylclobazam; 7‐COOH‐CBD, 7‐carboxy‐cannabidiol; 7‐OH‐CBD, 7‐hydroxy‐cannabidiol; CBD, cannabidiol; CLB, clobazam; CYP, cytochrome P450; N‐CLB, N‐desmethylclobazam; STP, stiripentol; UGT, uridine 5′‐diphospho‐glucoronosyltransferase; VPA, valproate