Algorithm 1. Trajectory optimization framework

Step 1: Acquire image data to be used as a digital phantom for DRR simulation Step 2: Define a set of arcs for the search space Step 3: Simulate DRRs for all defined arcs with the digital phantom Step 4: FOR 1: number of arcs Reconstruct the image using the set of DRRs related to the corresponding arc Crop the reconstructed image at the VOI Calculate the objective function at the cropped area ENDFOR Step 5: Find the best candidate as $ar{c}_{\mathit{max}}\left(\mathit{objectivefunction}\right)$ and remove it from the search space Step 6: Append best candidate to all other arcs in the search space Step 7: IF NOT stopping criteria are met Go to Step 4 ENDIF Step 8 Return selected trajectory (combined arcs)