Figure 2.

Altered transcription profiling and signaling pathways induced by FAM188B knockdown (A,B) A549 cells were transfected either with NC siRNA or siFAM188B for 48 h, followed by mRNA purification and RNAseq analysis. Downregulated genes by siFAM188B from RNAseq data were subjected to gene set enrichment analyses for gene ontology (GO)-biological process (A) and ChIP-X Enrichment Analysis (ChEA 2016) gene sets (B). Predictions of protein–protein interactions of downregulated genes categorized into forkhead box M1 (FOXM1) transcription factor network (C) and mitotic-phase transition by String-DB database (D).