Figure 2.

Experimental and model data comparison for varying organocatalysts and fuel concentrations, showing the conversion of p‐nitrophenol(ate) (1; start: 0.1 mm) in MOPS buffer (100 mm, pH 7.5) with 5 % acetonitrile. A) Simplified chemical reaction network with pyridine and imidazole catalyzing ester formation, ester hydrolysis, anhydride hydrolysis, and blank reactions. B) Fuel variation: 0.25/0.5/0.75 mm acetic anhydride (2), 0.25 mm imidazole, and 0.1 mm pyridine. C) Catalyst variation: 0.5 mm acetic anhydride (2), 0.1/0.25/0.5 mm imidazole, and 0.1 mm pyridine. D) Extreme situations: 0.5 mm acetic anhydride (2), 0/0.25 mm imidazole and 0/0.1 mm pyridine. The presented experimental data are equal to Figure 1. Details of the kinetic model are provided in the Supporting Information.