Table 1.
Autoimmune symptoms in mice with enhanced anti-tumor immunity. Models are ranked by severity of the syndrome.
| Protein/Family | Mouse Model | Autoimmune Symptoms | Lethality | Ref. |
|---|---|---|---|---|
| IKKβ | Foxp3creIkbkbF/F | Scurfy-like syndrome | Yes | [87] |
| Ezh2 | Foxp3creEzh2F/F | From 1 month of age, spontaneous T conv cell activation and tissue infiltration | Yes | [108] |
| IRF4 | Foxp3creIrf4F/F | From 6 to 8 weeks of age, spontaneous T conv cell activation and tissue infiltration | Yes | [38] |
| Id proteins | Foxp3creId2Tg | From 6 to 8 weeks of age, progressive T conv cell activation and tissue infiltration | Yes | [77] |
| STAT3 | Foxp3creStat3F/F | From 6 to 8 weeks of age, splenomegaly and colon inflammation | Yes | [80] |
| Bach2 | Bach2−/− | From 3 months of age, spontaneous T conv cell activation and tissue infiltration | Yes | [70] |
| P300 | Foxp3creep300F/F | From 10 weeks of age, spontaneous T conv cell activation and tissue infiltration | n.d. | [117] |
| CBM complex | Foxp3creBcl10F/F | Scurfy-like syndrome | Yes | [89] |
| Foxp3creMalt1F/C4712A | from 6 to 8 weeks of age, spontaneous T conv cell activation and tissue infiltration | n.d. | [88] | |
| Foxp3cre/+Carma1F/F | No detectable signs of autoimmunity (Foxp3cre/cre Carma1 F/F develop Scurfy-like syndrome) | No | [86] | |
| NF-κB | Foxp3creRelF/F | Mild lymphoproliferation from 20 weeks of age | No | [90] |
| Helios | Foxp3creIkzf2F/F | From 5 months of age, spontaneous T conv cell activation and tissue infiltration | No | [52] |
| Foxo1 | Foxp3creFoxo1CA/+ | No detectable signs of autoimmunity (Foxo1CA/CA develop lethal autoimmunity) | No | [30] |
| Pten | Foxp3crePTENF/F | From 12 weeks of age, spontaneous T conv cell activation, kidney damage | No | [136] |
| Foxp3crePTENF/F (2nd construct) | No detectable signs of autoimmunity | No | [41] | |
| Nr4a | Foxp3creNr4a1F/FNr4a2F/F dKO | No detectable signs of autoimmunity (Nr4a1/3 dKO and Nr4a1/2/3 tKO develop lethal autoimmunity) | No | [63] |
| PI3K | Foxp3crep110dF/F | No detectable signs of autoimmunity | No | [44] |
n.d.: not described; dKO: double knock-out; tKO: triple knock-out.