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. 2020 Aug 29;598(21):4907–4925. doi: 10.1113/JP280090

Figure 1. Reduced pilocarpine‐induced tear secretion in male NOD mice at and after 6 weeks of age.

Figure 1

A, the experimental design for measurement of tear secretion. We measured the length of the colour‐changed phenol red‐impregnated thread to estimate tear volume. We also weighed the saliva‐saturated paper plugs and corrected for the original plug weight to estimate saliva volume, which was measured simultaneously with tear volume, in the same mice. B–D, body weight‐adjusted tear volume for 30 s in every 2 min in BALB/c and NOD mice at each time point after pilocarpine treatment, at 4, 6 and 10 weeks of age, respectively. E, total tear volume after pilocarpine treatment in male BALB/c and NOD mice at 4, 6 and 10 weeks of age. F, maximum tear volume in male BALB/c and NOD mice at 4, 6 and 10 weeks of age. The obtained values are presented as mean ± SD: * p < 0.05, ** p < 0.01 versus BALB/c group. All experiments were conducted with 3–5 animals in each group.