Figure 8. Partial inhibition of pilocarpine‐induced saliva secretion by oral administration of an arginase 1 inhibitor.
A, body weight‐adjusted saliva volume in male BALB/c mice administered an arginase 1 inhibitor. BALB/c mice were orally administered an arginase 1 inhibitor, CB‐1158, at 100 mg kg−1, or the control (water), 2 h before pilocarpine treatment. B, total saliva volume after pilocarpine treatment. C, maximum saliva volume. The obtained values are presented as the mean ± SD: * p < 0.05 versus control group. All experiments were conducted with four or five animals in each group.