Table 2.
Antibacterial activity of QA-PEI nanoparticles prepared with the ethylene glycol bis(chloroacetate) crosslinker and different alkylation agent chain lengths against S. aureus and P. aeruginosa. Data from [84].
| Alkyl Bromide | Crosslinking Agent | Crosslinking Ratio | Antibacterial Activity 1 | |
|---|---|---|---|---|
| S. aureus | P. aeruginosa | |||
| 1-bromooctane | Ethylene glycol bis(chloroacetate) | 1:0.02 | >6 | 5.0 |
| 1:0.04 | >6 | 4.3 | ||
| 1:0.06 | >6 | 3.8 | ||
| 1:0.08 | 4.8 | 2.5 | ||
| 1:0.1 | 4.6 | <1.8 | ||
| 1-bromododecane | Ethylene glycol bis(chloroacetate) | 1:0.02 | 4.9 | 1.6 |
| 1:0.04 | 4.4 | <1.5 | ||
| 1:0.06 | 4.2 | <1.5 | ||
| 1:0.08 | 3.7 | <1.5 | ||
| 1:0.1 | 3.3 | <1.5 | ||
| 1-bromohexadecane | Ethylene glycol bis(chloroacetate) | 1:0.02 | 3.5 | <1.5 |
| 1:0.04 | 3.2 | <1.5 | ||
| 1:0.06 | 2.8 | <1.5 | ||
| 1:0.08 | 2.6 | <1.5 | ||
| 1:0.1 | 1.8 | <1.5 | ||
1 Antibacterial activity was calculated using Equation (1).